GENSCAN COMPLEX

Oncogenetics deals with hereditary predispositions to the development of malignant tumor diseases.

Approximately 5-10% of these diseases result from known mutations in genes involved in the body's defense mechanisms. Carriers of these mutations have a very high probability of developing tumor diseases during their lifetime.

Individuals with confirmed highly-risky mutations in these genes receive much more thorough preventive care in specialized medical facilities, in comprehensive oncology centers.

Screening examination of variants in 4 genes predisposing to breast, ovarian, or prostate cancer.

Chronic digestive issues are very common, yet it's relatively difficult to determine what causes them.

Primary food intolerance arises due to a genetic disorder, leading to an inability to digest certain foods, which causes digestive problems. The most common ones include lactose intolerance, histamine intolerance, fructose intolerance, celiac disease, non-specific intestinal inflammation, or Crohn's disease. Accurate diagnosis is crucial for effective treatment.

Genetic analysis can help confirm, exclude, or refine the diagnosis, allowing for appropriate therapeutic or preventive measures to be implemented, reducing the risks of health complications and improving quality of life.

List of tested chapters:

lactose intolerance
histamine intolerance
fructose intolerance
celiac disease
non-specific intestinal inflammation
Crohn's disease

Neurogenetics examines the occurrence of risk mutations or predispositions for the most common neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and hereditary forms of migraine.

Less severe but more common gene mutations do not directly cause the disease but can influence the age of onset, individual development, and progression of the disease. Especially in the case of dementia, genetics enables precise diagnosis and increases the success of potential treatment.

List of tested chapters:

• Alzheimer's disease
• Parkinson's disease
• hereditary forms of migraine

The sensory genetics panel examines genetic predispositions for various sensory organ disorders, including non-syndromic congenital hearing loss, age-related macular degeneration, age-related cataracts, primary open-angle glaucoma, and periodontitis.

It also includes several rare congenital eye and ear diseases. Predispositions for multifactorial eye diseases developing in later life, such as cataracts and macular degeneration, are also assessed.

If these diseases are not detected early, there is a risk of complete vision loss, making prevention absolutely crucial.

List of tested chapters:

• non-syndromic congenital hearing loss
• age-related macular degeneration
• age-related cataracts
• primary open-angle glaucoma
• periodontitis

Cardiogenetics evaluates inherited predispositions to heart and vascular diseases, which are the leading causes of mortality in our population.

The risk factors for these diseases primarily include high cholesterol, high blood pressure, increased blood clotting, chronic inflammation in the vascular wall, and inadequate antioxidant protection of the body.

We test genes that contribute to the development of these risk factors.

The analysis specifically examines the following areas:

• Heart attack and stroke
• Thrombosis
• Hypertension, including salt sensitivity
• Familial hypercholesterolemia
• Beta-thalassemia
• Arrhythmias
• Chronic venous insufficiency and varicose veins
• HDL-cholesterol
• LDL-cholesterol
• Homocysteine
• Inflammatory response
• Antioxidant capacity
• Effects of stress

Metabolism, or metabolic processes, encompasses the complex of all reactions that ensure the functioning of our organism.

We test not only metabolic disorders caused by mutations in a single gene but also predispositions to civilization metabolic diseases, including diabetes mellitus or diabetes, obesity, hemochromatosis, Wilson's disease, Gilbert's syndrome, and gout.

These diseases arise from the interaction between genes and lifestyle. This is especially true for diabetes and obesity, the development of which can be prevented in more than 90% of cases by following targeted preventive recommendations.

List of tested chapters:

diabetes mellitus
obesity
hemochromatosis
Wilson's disease
Gilbert's syndrome
gout

Our genes can have a significant impact on the effectiveness of specific medications and therefore the entire treatment process. In predisposed individuals, medications can cause serious adverse effects, or they may be completely ineffective.

A comprehensive pharmacogenetic panel evaluates the speed of drug activation or metabolism, its concentration in the blood, treatment efficacy, and the risk of adverse effects.

With this information, the most suitable and effective medications can be chosen, appropriate dosages can be determined, and the risk of adverse effects can be minimized.

Reproductive genetics is linked to reproductive medicine and assisted reproduction.

Genetic analysis allows us to determine whether one or both partners carry a genetic mutation that could cause serious illness or congenital defects in their offspring, or it seeks the cause of infertility or recurrent miscarriages.

We examine so-called thrombophilic mutations, which increase the risk of miscarriage and other pregnancy complications, genes related to fertility disorders, and hereditary predispositions to serious congenital diseases (especially in families where a congenital developmental defect or disease has already occurred).

List of tested chapters:

• fertility disorders
• risk of pregnancy complications,
• transmission of the most common congenital diseases,
• the need for supplementation in pregnancy.

Immunogenetics deals with the interconnection of immunology, genetics, and human metabolism. The panel evaluates primarily the readiness of the immune system to combat infectious diseases and the risk of developing chronic inflammation. Chronic inflammation in the body represents a risk factor for the development of a wide range of civilization diseases. In case of identifying risk gene variants, their effects can be mitigated through lifestyle adjustments and consistent treatment of inflammation.

List of tested panels:

• susceptibility to acute viral infections
• risk of severe course of viral infections
• predisposition to chronic inflammation and its impact on the development of civilization diseases
• chronic obstructive pulmonary disease
• ankylosing spondylitis
• alopecia

The human body encounters a large number of foreign and harmful substances daily, which undergo detoxification, meaning they are gradually transformed into less toxic substances and excreted from the body.

Although the body has effective protective mechanisms, their activity is largely influenced by our genetic makeup.

In the analysis, we evaluate antioxidant capacity and the ability to detoxify various heavy metals, alcohol, nicotine, caffeine, cigarette smoke by-products, and air pollution.

List of tested chapters:

antioxidant capacity
detoxification of alcohol
detoxification of caffeine
detoxification of nicotine
detoxification of PAH (polycyclic aromatic hydrocarbons - formed during the combustion of coal, oil, gas, waste, tobacco, meat, etc.)
detoxification of heavy metals

Osteoporosis is a progressive condition characterized by excessive loss of bone mass, leading to weakened and brittle bones that are prone to fractures.

Many factors contribute to its development, including genetics. However, for most individuals, the disease can be effectively managed through appropriate measures and lifestyle adjustments.

Genetic analysis reveals insights into the direction of preventive measures to be taken.