If you meet any of these indications, please contact us at
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TromboGen®
Detects the risk of thrombosis
The TromboGen® genetic analysis can detect innate predispositions to increased blood clotting and allows you to take the necessary preventive measures in time. Thrombosis is a blood clot that can cause serious health complications, in extreme cases even death. It is caused by slowed blood flow and/or altered blood composition due to the joint effects of external risk factors and hereditary predispositions.
IN WHICH SITUATIONS IT IS APPROPRIATE TO TAKE THE TEST
PERSONAL MEDICAL HISTORY
Previous venous thrombosis or pulmonary embolism.
FAMILY MEDICAL HISTORY
Family history of thrombosis or thrombophilic mutation.
HORMONAL CONTRACEPTIVES
You are taking or planning to take hormonal contraceptives.
HORMONAL THERAPY
You're undergoing hormone therapy.
DISEASES AND OPERATIONS
You have a cardiovascular or cancer disease, you are facing surgery.
LIFESTYLE
You travel by plane, you sit for long periods of time, you are a smoker, you are obese.
PREGNANCY
You are pregnant or planning to become pregnant.
PUBLIC HEALTH INSURANCE COVERS THE TEST IN THE FOLLOWING SITUATIONS
- In patients with a personal history of idiopathic thromboembolic disease (TED).
- Before starting hormonal contraceptives or hormone replacement therapy in women who have had TED or if a first-degree blood relative has had TED.
- For women who have had 3 spontaneous abortions in the first trimester of pregnancy or for any fetal loss in later pregnancy.
- For pregnant women if they have had TED or if any of their first-degree blood relatives have had TED.
- In pregnant women in the case of pre-eclampsia, fetal growth retardation or placental abruption.
- In case of Leiden or prothrombin mutation in first-degree relatives (testing of children is performed after 12 years of age, in exceptional cases earlier).
DETAILED INFORMATION
Thrombosis is a cardiovascular disease that can cause serious complications, permanent sequelae and, in extreme cases, death. External risk factors and our genetic predisposition are involved in the development of thrombosis. The most common risk factors include smoking, being overweight, varicose veins, high cholesterol, hormonal contraceptives, cancer or cardiovascular disease, sitting or standing for long periods of time, dehydration, frequent or long plane trips, and surgery. The risk of thrombosis increases with age.
The most common serious and life-threatening complication of venous thrombosis is pulmonary embolism, when a blood clot breaks loose and causes blockage of a pulmonary artery and subsequent cardiac arrest. The TromboGen® genetic analysis, which can detect thrombophilic mutations involved in blood clotting, can make a significant contribution to preventing venous thrombosis and minimising potential complications. Based on the results of this analysis, you can take appropriate measures to reduce your risk of venous thrombosis.
The TromboGen® genetic analysis examines thrombophilic mutations in the F5 and F2 genes. Mutation in the F5 gene (Leiden mutation) leads to increased blood clotting and increased risk of deep vein thrombosis and thromboembolic disease. Pregnant women with this mutation are at increased risk of complications, especially spontaneous abortion, premature placental abruption or fetal growth retardation (IUGR). The F2 mutation (prothrombin G20210A mutation) carries an increased risk of deep vein thrombosis and thromboembolic disease, including the risks during pregnancy mentioned for the F5 mutation.
You will receive the result within 10 working days.
HOW DOES THE WHOLE PROCESS WORK?
After ordering the test, you will receive an email with detailed information. A DNA sample is most often obtained through an oral swab or blood sample. You can perform the oral swab yourself in the comfort of your own home using a collection kit which will be sent to you by mail together with instructions and other documents. You can have your blood drawn at your local physician's office or at our outpatient clinic. The result of the analysis will be sent to you by e-mail or by post as agreed. In the case of a positive result, we recommend an appointment for a genetic consultation.
1.
Ordering
Choose a specific test or make an appointment for a genetic consultation.2.
Sampling
A sample of your DNA is most often obtained through an oral swab or blood sample.3.
Analysis
Our team of experienced professionals will analyse the sample using the latest methods and technologies.4.
RESULT
After the test has been evaluated, you will receive a detailed and easy-to-understand laboratory report, or a consultation with a clinical geneticist will be recommended.Frequently Asked Questions
The time required for the laboratory examination (sample analysis) and the delivery date of the result vary according to the type and complexity of the examination. Usually it is in the order of weeks, for complex tests up to several months. The delivery date of the result is indicated in the details of each test on our website. In urgent situations, e.g. for a woman with a newly diagnosed breast or ovarian tumour before surgery, the oncopanel cancer test is performed in STATIM mode and the result is available within 3-4 weeks, whereas in normal mode it takes up to 6 months.
Health insurance always covers genetic consultations recommended by the attending physician (usually a general practitioner, paediatrician, oncologist, gynaecologist or other specialist). During the consultation, a clinical geneticist will assess whether the indication criteria for testing for the predisposition genes are met; if so, the entire genetic test, including laboratory analysis of the sample and subsequent consultation with the geneticist/doctor, is covered by health insurance. If the criteria for the genetic testing are not met, the patient can pay for the selected/recommended test as a self-payment.
After making an appointment, you will come to our office where you will first fill out a personal and family history questionnaire, or you can download it from here on our website and fill it out in advance, in the comfort of your own home. Remember to bring it with you afterwards. This is followed by a consultation with a doctor who will compile your three-generation family tree and decide on the indication for laboratory genetic testing. We also recommend that you bring medical reports from recent important examinations.
Recommendation - a referral from the doctor who recommended the genetic consultation. Alternatively, a completed genetic family and personal history questionnaire, which can be downloaded here. However, the questionnaire can also be completed after you arrive at our office. Medical reports from previous examinations related to the requested genetic test. It is not necessary to be fasting for the genetic examination, so you can easily make an appointment in the afternoon.
It has been reported that approximately 5-10% of cancers are caused by inborn changes in certain genes. One of the main goals of predictive genetic testing is the early identification of people at risk. If risk predispositions (gene mutations) are detected, preventive follow-up at specialised centres is recommended, where possible cancers are detected early and the chances of successful treatment are increased. In the case of high-risk mutations, preventive surgery may be recommended to make the risk of cancer in a given organ virtually impossible (for example, removal of the breast glands or removal of the uterus and ovary in BRCA1 or BRCA2 mutation carriers).
If your first-degree relative (parents, siblings, children) develops colon cancer before the age of 45, your risk of developing this cancer is 5 times higher. If you have three first-degree relatives, your risk can be as high as 50%. In families with a history of recurrent bowel cancer or with a history of bowel cancer at a young age, it could be hereditary cancer syndrome (Lynch syndrome). In such cases, genetic consultation is recommended.