We offer a new examination "Pharmacogenetics of statins"

Statins inhibit the internal production of cholesterol in the liver, leading to a reduction in total and LDL-cholesterol levels in the blood. However, in a proportion of the population, they cause muscular side effects, particularly myopathy, which can lead to the development of rhabdomyolysis. The more common manifestation of myopathy in the form of muscle pain, weakness or fatigue is a common reason why patients stop taking the medication.

In terms of the innate predisposition of statins in the human body, the most important membrane transporter is OATP1B1, which ensures the transfer of substances into cells. Carriers of the tested mutation have reduced statin entry into liver cells. The drug is then less effective and, in addition, it remains in the blood, where its plasma concentration rises, significantly increasing the risk of side effects. Dosage adjustment is therefore recommended for mutation carriers.

• Clients will receive the result within 10 working days.
• The price of the test for self-payers is set at 2900 CZK.