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Tumour syndromes
Wide spectrum of genes to be tested
Genetic analysis of 88 risk genes that are associated with certain inherited diseases, particularly breast and ovarian, colorectal, pancreatic, prostate and other cancers. The genetic analysis result will give you an answer as to whether you have a hereditary predisposition to cancer and, if necessary, allow you to take the necessary measures in time. A number of factors are involved in the development of tumours; apart from hereditary predispositions, these include external influences and lifestyle factors.
IN WHICH SITUATIONS IT IS APPROPRIATE TO TAKE THE TEST
EARLY PREVENTION
You want to prevent potential risks in time.
PERSONAL MEDICAL HISTORY
History of cancer in the past.
FAMILY MEDICAL HISTORY
Family history of cancer.
POSITIVE DIAGNOSIS
Before choosing an appropriate treatment in case of illness.
WEIGHT LOSS
You lose weight and suffer from fatigue.
PUBLIC HEALTH INSURANCE COVERS THE TEST IN THE FOLLOWING SITUATIONS
If you have a personal and/or family history of cancers (colon or small bowel cancer, uterine cancer, kidney cancer, etc.), genetic analysis may also be covered by public health insurance after a risk assessment by a clinical geneticist.
Schedule a genetic consultation.
DETAILED INFORMATION
Tumour diseases are divided into malignant that grow into the surrounding tissue and invade other organs, and benign, which grow only to a certain limit but can still oppress surrounding tissue and cause problems. The most common hereditary cancers include breast and ovarian cancer, prostate cancer, skin cancer, stomach cancer, thyroid cancer, kidney cancer, colorectal cancer, and various types of leukaemia.
Smoking, excessive alcohol consumption, unhealthy diet, lack of exercise, exposure to certain chemicals and others are among the most risky external influences for developing the disease. The elimination of these risk factors and regular preventive examinations can help prevent cancer. People of reproductive age with a proven gene mutation can be offered preimplantation diagnosis as part of IVF and, by selecting a suitable embryo, avoid transmission of the risk disposition to the next generation.
Our laboratory is internationally accredited for hereditary cancer predisposition testing using massively parallel sequencing with a “Custom design Roche” cancer panel and other methods. We use the latest PILOT software and bioinformatic procedures for data analysis. We regularly participate in inter-laboratory audits and, thanks to our connection with an expert consortium, update the most accurate diagnostic procedures for cancer predisposition.
You will receive the result in 3-6 months.
HOW THE TEST WORKS AND WHAT YOU CAN EXPECT
After ordering the test, you will receive an email with detailed information. A DNA sample is most often obtained through an oral swab or blood sample. You can perform the oral swab yourself in the comfort of your own home using a collection kit, which will be sent to you by mail together with instructions and other documents. You can have your blood drawn at your local physician's office or at our outpatient clinic. The result of the analysis will be sent to you by e-mail or by post as agreed. In case of a positive result, we will arrange a consultation with a clinical geneticist who will explain everything and recommend appropriate measures.
1.
Ordering
Choose a specific test or make an appointment for a genetic consultation.2.
Sampling
A sample of your DNA is most often obtained through an oral swab or blood sample.3.
Analysis
Our team of experienced professionals will analyse the sample using the latest methods and technologies.4.
RESULT
After the test has been evaluated, you will receive a detailed and easy-to-understand laboratory report, or a consultation with a clinical geneticist will be recommended.Frequently Asked Questions
The time required for the laboratory examination (sample analysis) and the delivery date of the result vary according to the type and complexity of the examination. Usually it is in the order of weeks, for complex tests up to several months. The delivery date of the result is indicated in the details of each test on our website. In urgent situations, e.g. for a woman with a newly diagnosed breast or ovarian tumour before surgery, the oncopanel cancer test is performed in STATIM mode and the result is available within 3-4 weeks, whereas in normal mode it takes up to 6 months.
Health insurance always covers genetic consultations recommended by the attending physician (usually a general practitioner, paediatrician, oncologist, gynaecologist or other specialist). During the consultation, a clinical geneticist will assess whether the indication criteria for testing for the predisposition genes are met; if so, the entire genetic test, including laboratory analysis of the sample and subsequent consultation with the geneticist/doctor, is covered by health insurance. If the criteria for the genetic testing are not met, the patient can pay for the selected/recommended test as a self-payment.
After making an appointment, you will come to our office where you will first fill out a personal and family history questionnaire, or you can download it from here on our website and fill it out in advance, in the comfort of your own home. Remember to bring it with you afterwards. This is followed by a consultation with a doctor who will compile your three-generation family tree and decide on the indication for laboratory genetic testing. We also recommend that you bring medical reports from recent important examinations.
Recommendation - a referral from the doctor who recommended the genetic consultation. Alternatively, a completed genetic family and personal history questionnaire, which can be downloaded here. However, the questionnaire can also be completed after you arrive at our office. Medical reports from previous examinations related to the requested genetic test. It is not necessary to be fasting for the genetic examination, so you can easily make an appointment in the afternoon.
It has been reported that approximately 5-10% of cancers are caused by inborn changes in certain genes. One of the main goals of predictive genetic testing is the early identification of people at risk. If risk predispositions (gene mutations) are detected, preventive follow-up at specialised centres is recommended, where possible cancers are detected early and the chances of successful treatment are increased. In the case of high-risk mutations, preventive surgery may be recommended to make the risk of cancer in a given organ virtually impossible (for example, removal of the breast glands or removal of the uterus and ovary in BRCA1 or BRCA2 mutation carriers).
If your first-degree relative (parents, siblings, children) develops colon cancer before the age of 45, your risk of developing this cancer is 5 times higher. If you have three first-degree relatives, your risk can be as high as 50%. In families with a history of recurrent bowel cancer or with a history of bowel cancer at a young age, it could be hereditary cancer syndrome (Lynch syndrome). In such cases, genetic consultation is recommended.