If any of these indications apply to you, please contact us:
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TromboGen Plus®
Reveals the risk of thrombosis development
The TromboGen Plus® genetic analysis can identify inherited predispositions to increased blood clotting, enabling you to take timely preventive measures. Thrombosis is a blood clot that can lead to severe health complications and, in extreme cases, death. It occurs due to a slowing of blood flow and/or changes in blood composition, resulting from the interaction of external risk factors and genetic predispositions.
Special offer for OZP insured clients – in December, you can get a 50% discount on the TromboGen Plus® test (find the discount code at vitashop.ozp.cz).
IN WHICH SITUATIONS IT IS APPROPRIATE TO TAKE THE TEST
PERSONAL MEDICAL HISTORY
Previous venous thrombosis or pulmonary embolism.
FAMILY MEDICAL HISTORY
Family history of thrombosis or thrombophilic mutation.
HORMONAL CONTRACEPTIVES
You are taking or planning to take contraception.
HORMONAL THERAPY
You're undergoing hormone therapy.
DISEASES AND OPERATIONS
You have a cardiovascular or cancer disease, you are facing surgery.
LIFESTYLE
You travel by plane, you sit for long periods of time, you are a smoker, you are obese.
PREGNANCY
You are pregnant or planning to become pregnant.
PUBLIC HEALTH INSURANCE COVERS THE TEST IN THE FOLLOWING SITUATIONS
- In patients with a personal history of idiopathic thromboembolic disease (TEN).
- Before starting hormonal contraceptives or hormone replacement therapy in women who have had TEN or if a first-degree blood relative has had TEN.
- In women who have had 3 spontaneous abortions in the first trimester of pregnancy, or for any fetal loss in later pregnancy.
- In pregnant women if they have had TEN or if any of their first-degree blood relatives have had TEN.
- In pregnant women in case of pre-eclampsia, fetal growth retardation or placental abruption.
- In case of Leiden or prothrombin mutation in first-degree relatives (children should be examined after 12 years of age, in exceptional cases earlier).
DETAILED INFORMATION
The basic genetic analysis TromboGen® examines thrombophilic mutations in the F5 and F2 genes. A mutation in the F5 gene (Leiden mutation) results in increased blood clotting and an elevated risk of deep vein thrombosis (DVT) and thromboembolic disease. In pregnant women, this mutation is associated with a higher risk of complications, particularly spontaneous miscarriages, premature placental abruption, or intrauterine growth restriction (IUGR). A mutation in the F2 gene (prothrombin mutation G20210A) also increases the risk of deep vein thrombosis and thromboembolic disease, as well as pregnancy-related risks similar to those associated with the F5 mutation.
The Trombogen Plus® genetic analysis additionally examines mutations in the PAI1 4G/5G gene, which are linked to a higher risk of developing cardiovascular diseases, such as coronary syndrome, myocardial infarction, stroke, thrombosis, and potential complications following surgical procedures.
Thrombosis is a cardiovascular disease that can lead to serious complications, permanent consequences, and, in extreme cases, death. Its development is influenced by external risk factors and genetic predispositions. The most common risk factors include smoking, obesity, varicose veins, high cholesterol, hormonal contraception, oncological or cardiovascular diseases, prolonged sitting or standing, dehydration, frequent or long air travel, and surgical procedures. The risk of developing thrombosis increases with age.
You will receive the result within 10 working days.
HOW DOES THE WHOLE PROCESS WORK?
After ordering the test, you will receive an email with detailed instructions. You can collect a sample from your oral cavity yourself, in the comfort of your home, using the collection kit we will send you by mail along with a manual and additional documents. The analysis results will be sent to you as agreed, either via email or postal service. In case of a positive finding, we recommend scheduling a genetic consultation.
Frequently Asked Questions
The time required for the laboratory examination (sample analysis) and the delivery date of the result vary according to the type and complexity of the examination. Usually it is in the order of weeks, for complex tests up to several months. The delivery date of the result is indicated in the details of each test on our website. In urgent situations, e.g. for a woman with a newly diagnosed breast or ovarian tumour before surgery, the oncopanel cancer test is performed in STATIM mode and the result is available within 3-4 weeks, whereas in normal mode it takes up to 6 months.
Health insurance always covers genetic consultations recommended by the attending physician (usually a general practitioner, paediatrician, oncologist, gynaecologist or other specialist). During the consultation, a clinical geneticist will assess whether the indication criteria for testing for the predisposition genes are met; if so, the entire genetic test, including laboratory analysis of the sample and subsequent consultation with the geneticist/doctor, is covered by health insurance. If the criteria for the genetic testing are not met, the patient can pay for the selected/recommended test as a self-payment.
After making an appointment, you will come to our office where you will first fill out a personal and family history questionnaire, or you can download it from here on our website and fill it out in advance, in the comfort of your own home. Remember to bring it with you afterwards. This is followed by a consultation with a doctor who will compile your three-generation family tree and decide on the indication for laboratory genetic testing. We also recommend that you bring medical reports from recent important examinations.
Recommendation - a referral from the doctor who recommended the genetic consultation. Alternatively, a completed genetic family and personal history questionnaire, which can be downloaded here. However, the questionnaire can also be completed after you arrive at our office. Medical reports from previous examinations related to the requested genetic test. It is not necessary to be fasting for the genetic examination, so you can easily make an appointment in the afternoon.
It has been reported that approximately 5-10% of cancers are caused by inborn changes in certain genes. One of the main goals of predictive genetic testing is the early identification of people at risk. If risk predispositions (gene mutations) are detected, preventive follow-up at specialised centres is recommended, where possible cancers are detected early and the chances of successful treatment are increased. In the case of high-risk mutations, preventive surgery may be recommended to make the risk of cancer in a given organ virtually impossible (for example, removal of the breast glands or removal of the uterus and ovary in BRCA1 or BRCA2 mutation carriers).
If your first-degree relative (parents, siblings, children) develops colon cancer before the age of 45, your risk of developing this cancer is 5 times higher. If you have three first-degree relatives, your risk can be as high as 50%. In families with a history of recurrent bowel cancer or with a history of bowel cancer at a young age, it could be hereditary cancer syndrome (Lynch syndrome). In such cases, genetic consultation is recommended.