The days of testing for thrombophilic mutations
The days of testing for thrombophilic mutations
When, where, and how to sign up?
HOW?
CAPACITY IS FULL.
If you already have a reservation, please remember to fill out a short questionnaire.
WHEN?
On weekdays from October 14th to 25th,
7:30-8:30 and 15:30-16:30.
WHERE?
GHC Genetics, s.r.o.
V Holešovičkách 1156/29
Prague 8
How does the whole process work?
It is a painless, non-invasive examination.
1) First, BOOK your appointment and then fill out our online QUESTIONNAIRE.
2) One hour before the examination, please do not eat, drink anything other than still plain water, chew gum, or smoke.
3) Arrive at the GHC Genetics clinic at your scheduled time: V Holešovičkách 29, Prague 8.
4) At the reception, they will check your reservation and the completed genetic questionnaire. A healthcare professional will then take a swab from your mouth.
The analysis takes approximately 4 weeks. We will inform you of the test result via email or phone.
The partner of the Days of Testing for Thrombophilic Mutations is GeneProof.
Risk factors for thrombosis
Surgery
Thrombosis is one of the most common complications, especially in orthopedic procedures on the lower limbs, as blood flow in the veins slows down due to the inactivity of muscles that normally pump blood from the limbs toward the heart. During surgery, blood vessels can also be damaged, releasing substances that promote blood clotting, which can also lead to the formation of thrombosis. The solution is the administration of anticoagulant medication.
Contraception
Using hormonal contraception makes the blood more prone to clotting. The risk of developing blood clots is 2–4 times higher for users of hormonal contraception compared to women who do not use it.
Long Flights
Blood flow in the lower limbs slows down due to reduced mobility during long flights (over 5 hours).
Cancer
Cancers produce substances that increase blood clotting. Up to 20% of cancer patients may die from the consequences of pulmonary embolism. The solution is the administration of anticoagulant medication.
Symptoms of thrombosis
- Increased tension or swelling
- Pain that worsens with movement
- Redness in the affected area
- Warm skin in the affected area
In deep vein thrombosis, clots (thrombi) form in the deep veins, most commonly in the lower limbs. Thrombosis is particularly dangerous due to the risk of pulmonary embolism, where a detached thrombus travels through the bloodstream to the lungs, blocking a vessel that supplies oxygen. This can lead to serious health complications.
Individuals with pronounced varicose veins, especially in combination with carrying thrombophilic mutations, are also at increased risk for venous thrombosis. These individuals may more frequently experience superficial vein thrombosis, which manifests as red, warm, and painful streaks in the affected area.
5-10 %
Approximately 5-10% of the Czech population carries the mutation of the F5 gene.
IT'S IN OUR GENES
One of the key risk factors for thrombosis is genetic predisposition.
VENOUS THROMBOSIS
It also affects young individuals, particularly women using hormonal contraception or those who are pregnant.
Test for mutations in the F5 and F2 genes.
The Leiden mutation in the F5 gene and the prothrombin mutation in the F2 gene lead to increased blood clotting. Carriers of these mutations have an elevated risk of developing deep vein thrombosis and thromboembolic disease.
Pregnant women face an increased risk of complications, particularly spontaneous miscarriages, premature placental abruption, or placental infarctions, which can lead to a gradual growth restriction of the fetus below the norm established for the given stage of pregnancy.
Examination of genetic predispositions to thrombosis.
From your sample, we will analyze a portion of DNA that contains the genetic information of the F5 and F2 genes. The functionality of these genes is essential for proper blood clotting. If these genes are damaged by a mutation, the blood clotting process does not work correctly, which increases the risk of developing venous thrombosis. Using modern methods, we will examine only the F5 and F2 genes.
You will not have to pay anything for the examination.
Partners
