| METABOLIZAČNÍ ENZYMY
|
SUBSTRÁTY
|
| CYP1A2 |
duloxetin, klozapin, olanzapin, melatonin, pirfenidon, ramosetron, ramelteon, tasimelteon, teofylin, tizanidin |
| CYP2C9 |
celocoxib, fenytoin, glimepirid, glipizid, glibenklamid, ibuprofen, irbesartan, kandesartan, losartan, tolbutamid, warfarin, další NSAIDs |
| CYP2C19 |
amitriptylin, citalopram, diazepam, doxepin, escitalopram, fenytoin, fluoxetin, imipramin, kanabidiol, klobazam, klomipramin, klopidogrel, lansoprazol, omeprazol, pantoprazol, sertralin, tofacitinib, vorikonazol |
| CYP2D6 |
amfetaminy, amitriptylin, aripiprazol, atomoxetin, brexpiprazol, desipramin, dextromethorphan, doxepin, dihydrokodein, duloxetin, fluoxetin, fluvoxamin, haloperidol, imipramin, klomipramin, kodein, metoprolol, nortriptylin, ondansetron, paroxetin, pitolisant, propafenon, risperidon, tamoxifen, tolterodin, tramadol, tropisetron, venlafaxin, vortioxetin, zuklopentixol
|
| CYP3A4/5 |
alfentanil, avanafil, budesonid, buspiron, conivaptan, darifenacin, darunavir, dasatinib, dronedaron, ebastin, eletriptan, eplerenon, everolimus, felodipin, ibrutinib, indinavir, lomitapid, lovastatin, lurasidon, maraviroc, midazolam, naloxegol, nisoldipin, quetiapin, sachinavir, sildenafil, simvastatin, sirolimus, tacrolimus, tikagrelor, tipranavir, tolvaptan, triazolam, vardenafil |
